منابع مشابه
Protein Folding: An unfolding story
A unified and coherent picture for the mechanism of protein folding is emerging. The crucial factor in folding is the cooperativity of multiple interactions that is required for stability of the folded state.
متن کاملCan protein unfolding simulate protein folding?
Since the discovery that the native structure of a globular protein can fold spontaneously (Anfinsen et al., 1961), numerous experimental and theoretical efforts have been made to elucidate folding pathways, intermediates, transition states, etc. (for recent reviews, see Bryngelson et al., 1995; Fersht, 1995, 1997; Karplus and Šali, 1995; Ptitsyn, 1995; Miranker and Dobson, 1996; Shakhnovich, 1...
متن کاملAn unfolding breast cancer story
RCA1 is one of the most intensely studied proteins in the history of cancer research, and it has more than its fair share of proposed protein partners and postulated activities. Rong Li hopes that he has made sense out of this mountain of information in a paper by Ye et al. starting on page 911. He and his coauthors suggest that BRCA1’s effects on transcription and DNA repair have as their root...
متن کاملFolding a protein in a computer: an atomic description of the folding/unfolding of protein A.
We study the folding mechanism of a three-helix bundle protein at atomic resolution, including effects of explicit water. Using replica exchange molecular dynamics we perform enough sampling over a wide range of temperatures to obtain the free energy, entropy, and enthalpy surfaces as a function of structural reaction coordinates. Simulations were started from different configurations covering ...
متن کاملPressure-induced protein-folding/unfolding kinetics.
We use an off-lattice minimalist model to describe the effects of pressure in slowing down the folding/unfolding kinetics of proteins when subjected to increasingly larger pressures. The potential energy function used to describe the interactions between beads in the model includes the effects of pressure on the pairwise interaction of hydrophobic groups in water. We show that pressure affects ...
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ژورنال
عنوان ژورنال: Current Biology
سال: 1995
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(95)00070-4